The experimental research of R-Salbutamol on inhibiting the contraction of isolated tracheal smooth muscle in guinea-pig
- VernacularTitle:左旋沙丁胺醇抑制豚鼠气道平滑肌收缩的实验研究
- Author:
Yun SUN
;
Wen TAN
;
Huazhu ZHOU
;
Qing LIU
- Publication Type:Journal Article
- Keywords:
R-salbutamol;
tracheal strips;
lung parenchyma strips
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evaluate the effects of R-Salbutamol(R-Sal)on the contraction of isolated tracheal strips and lung parenchyma strips in guinea-pig,induced by Histamine(His).Methods Tracheal strips and lung parenchyma strips of guinea-pig in vitro were prepared,and the dilatory effect on shrinkage reaction of isolating specimens induced by His were measured before or after the administration of R-Sal in doses of 10-8,10-7,10-6 mol?L-1,with fix-doses pharmacology methods.The inhibitory effect was compared with that of Sal(10-6 mol?L-1).Results His could induce the contraction of isolated strips in guinea-pig in a dose-dependent manner,and R-Sal could significantly inhibit this shrinkage of lung parenchyma induced by His.in a dose-dependent manner.R-Sal was much more efficient than Sal(P
