PTCH2 gene alterations in keratocystic odontogenic tumors associated with nevoid basal cell carcinoma syndrome
- VernacularTitle:伴痣样基底细胞癌综合征的牙源性角化囊性瘤中PTCH2基因的突变检测
- Author:
Lili XU
;
Tiejun LI
- Publication Type:Journal Article
- Keywords:
Keratosis;
Odontogenic cysts;
Basal cell nevus syndrome;
Genes;
Mutation
- From:
Journal of Peking University(Health Sciences)
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
T)of PTCH2 were identified and 9 polymorphisms (3 of which were novel) were determined in the present series. Conclusion: Although not as frequent as PTCH1 mutations, PTCH2 germline mutations were detectable in a subset of NBCCS patients with KCOTs. The pathogenetic role of these PTCH2 mutations is yet to be clarified.
