Trojan Peptides Based Nucleic Acids Delivery
- VernacularTitle:特洛伊肽运载核酸的研究进展
- Author:
Xiuqin LOU
;
Cheng ZHOU
- Publication Type:Journal Article
- Keywords:
Trojan peptides;
Cell-penetrating peptides;
Protein transduction domains;
Plasmid DNA;
siRNA
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Trojan peptides,also named cell-penetrating peptides or protein transduction domains,are a class of small cationic peptides that often contains less than 30 amino acids.They can deliver a wide range of "cargos" such as peptides,proteins and nucleic acids efficiently through the cellular membrane.This review mainly focuses on the recent progress on utilizing Trojan peptides to deliver plasmid DNA and siRNA into cells in vitro and in vivo,and also highlights the implications of this technology in both gene function study and therapeutic potential.
