Protective Effects of Salvia Miltiorrhiza on Small Intestinal Ischemia Reperfusion Injury During Intestinal Transplantation Induced by Cytokines in Rats
- VernacularTitle:细胞因子致鼠小肠移植中小肠缺血再灌注损伤及丹参保护作用的研究
- Author:
Bei LU
;
Yang CAI
;
Guanghua FENG
- Publication Type:Journal Article
- Keywords:
Reperfusion injury;
Small intestine;
Transplantation;
Cytokins;
Salvia miltiorrhiza
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effect of Salvia miltiorrhiza on small intestinal ischemia reperfusion injury during intestinal transplantation induced by cytokines in rats.Methods Sixty Sprague Dawley rats were randomly divided into sham operation group,model group and low,mid,high doze treatment group,the superior mesenteric artery was occluded and then released to simulate the model of small intestinal ischemia reperfusion during intestinal transplantation.Tumor necrosis factor-?,interleukin-1?,interleukin-8 both in the plasm and small intestinal tissue were evaluated by ELISA 2 hours after reperfusion,changes of pathology in intestinal mucosa were observed.Results TNF-?,IL-1?,IL-8 were significantly higer(P
