Effect of poly(ADP-ribose)polymerase inhibitor 5-AIQ on invasion and metastasis of CT26 cells
- VernacularTitle:PARP抑制剂5-AIQ对CT26细胞侵袭及转移的影响
- Author:
Ming LI
;
Li CAI
;
Yalan WANG
- Publication Type:Journal Article
- Keywords:
poly(ADP-ribose)polymerase;
5-AIQ;
colorectal neoplasm;
metastasis
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of poly(ADP-ribose)polymerase(PARP)inhibitor 5-AIQ on the adhesion,migration and invasion of mouse colon adenocarcinoma cell line(CT26).Methods The expression of PARP after 5-AIQ treatment was detected Western blot.The cell adhesion,migration and invasion of CT26 after 5-AIQ treatment were observed by cell-matrix adhesion assay,cell migration assay and matrigel invasion assay.Results The expression of PARP in 5-AIQ-treated CT26 was weaker than that in 5-AIQ-untreated cells(P
