Correlative Study between the Expression of IL-8mRNA,MCP-1mRNA and MIP-1? mRNA and the Counts of Tumor-associated Macrophage (TAM) and Mast Cell (MC) in Ovarian Adenocarcinoma Tissues
- VernacularTitle:卵巢腺癌组织中化学趋化因子mRNA表达与TAM、MC计数的相关性研究
- Author:
Feng LONG
;
Chenhong WANG
;
Bo XU
- Publication Type:Journal Article
- Keywords:
Ovarian adenocarcinoma;
Chemokines;
Tumor-associated macrophage;
Mast cell;
In situ hybridization;
Immunohistochemsitry
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on the expressions of IL-8mRNA,MCP-1mRNA and MIP-1mRNA and the counts of TAM and MC and their correlation in ovarian adenocarcinoma tissues.Methods detecting the expressive levels of IL-8mRNA,MCP-1mRNA In situ hybridization were derected,and MIP-1?mRNA and Envision immunohistochemistry wes used for the counts of TAM and MC.Results The positive rates of IL-8mRNA,MCP-1mRNA and MIP-1?mRNA expressions and the counts of TAM and MC were significantly lower in the cases of histologic grade G1,clinical stage Ⅰ+Ⅱ,no-metastasis of regional lymph node,and no-infiltration of peritumoral tissues than those in the ones of histologic grade G3,clinical stage Ⅲ+Ⅳ,metastasis of regional lymph node,and infiltration peritumoral tissues(P
