Effects of Sodium 2,3-Dimercapto-1-propanesulfonate (DMPS) on IL-1? during Experimental Myocardial Ischemia-Reperfusion Injury
- VernacularTitle:二巯基丙磺酸钠对兔急性心肌缺血再灌注损伤血清IL-1?的影响
- Author:
Haiyan ZHANG
;
Lingwen LI
;
Junyan CHENG
- Publication Type:Journal Article
- Keywords:
Sodium 2,3-Dimercapto-1-propanesulfonate(DMPS);
IL-1?;
Myocardial ischemia-reperfusioninjury
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of DMPS on IL-1? during experimental myocardial ischemia-reperfusion(I/R)injury.Methods 30 New Zealand rabbits were randomly assigned to 3 groups:I/R group,DMPS protection group and Control group,10 in each group.The blood samples was obtained through vien at different time(5 min before ischemia,the end of the ischemia period and 0.5h,1h,2h,4h,6h after reperfusion)in each group.The serum concentrations of IL-1? were detected with radioimmunology method.Cardiac tissues samples were taken for determination of IL-1?.The ultrastructure changes of the Cardiac tissues were observed.Results The levels of IL-1? of serum and cardiac tissues increased after ischemia and reperfusion,and were significant different comparing with that before ischemia(P
