Studies on mutagenicity of Schistosoma japonicum bivalent DNA vaccine
- VernacularTitle:日本血吸虫双价DNA疫苗的致突变性研究
- Author:
Dan CHEN
;
Youen SHI
;
Yuan HU
;
Xiaohua ZHU
- Publication Type:Journal Article
- Keywords:
Schistosoma japonicum;
Bivalent DNA vaccine;
Ames test;
Micronucleus test;
Chromosome aberration test
- From:
Chinese Journal of Schistosomiasis Control
1989;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the mutagenicity of Schistosoma japonicum bivalent DNA vaccine.Methods The mutagenicity of Schistosoma japonicum bivalent DNA vaccine was studied by Ames test,micronucleus test and chromosome aberration test.Results On the conditions of actived and unactived,Schistosoma japonicum bivalent DNA vaccine did not lead obvious increase of colony units,and the result of the Ames test was negative.Compared with the control group,there were no significant differences in the treated groups on the frequency of micronucleus in PCE or chromosome aberration.Conclusion There is no mutagenicity of Schistosoma japonicum bivalent DNA vaccine.
