EFFECTS OF LOW MOLECULAR WEIGHT POLYPEPTIDE EXTRACTED FROM CHICKEN EMBRYO ON LEARNING AND MEMORY IN AGING MICE INDUCED BY D-GALACTOSE
- VernacularTitle:鸡胚低分子多肽对D-半乳糖拟衰老小鼠学习记忆的影响
- Author:
Shu CHEN
;
Yunshao HE
;
Gang CHEN
;
Jinsong GAO
- Publication Type:Journal Article
- Keywords:
chicken embryo;
low molecular weight polypeptide;
D-galactose;
aging;
learning and memory
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of low molecular weight polypeptide(LMP) extracted from chicken embryo on learning and memory in senile mice induced by D-galactose(Gal). Method The 16 d old chicken embryo was acid and alkali hydrolyzed,enzymolyzed and ultrafiltered to formulate LMP. 48 mice were divided randomly into four groups: control,aging model ,aging+low dose LMP,aging+high dose LMP. The aging model and two LMP groups were treated with Gal 80 mg/ (kg bw?d) by nape subcutaneous injection,while the control group with normal saline 8ml/(kg bw?d). Control and model groups were given i.g. normal saline 20 ml/(kg bw?d),and two LMP groups 10 ml or 20 ml/(kg bw?d) LMP respectively. Learning and memory of mice were tested with Morris water maze. Results The escape latency of model group was longer and the percentage of swimming distance in platform region higher than that of control group (P
