STUDY ON ROLE OF C-MYC IN APOPTOSIS OF HUMAN GASTRIC CARCINOMA CELLS INDUCED BY PHYTIC ACID
- VernacularTitle:c-myc在植酸诱导人胃癌细胞凋亡中的作用研究
- Author:
Lu WANG
;
Zhiping YANG
;
Dan LI
;
Hongbin CUI
- Publication Type:Journal Article
- Keywords:
phytic acid;
apoptosis;
c-myc;
human gastric carcinoma cells
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of phytic acid on apoptosis of human gastric carcinoma SGC-7901 cells and its mechanism. Method The inhibiting action of phytic acid on SGC-7901 cells was examined by MTT assay; the morphology alteration of SGC-7901 cells was examined by reverse discrepancy microscope; and the expression of c-myc protein was detected by immunohistochemisty method and Western blot method. Results Phytic acid inhibited the growth of human gastric carcinoma SGC-7901 cells in dose and time dependent manner. The growth of cells in test groups were inhibited higher than in control group. The expression of c-myc protein in phytic acid group was lower compared with control group,and reduced in a dose-dependent manner. Conclusion Phytic acid can induce apoptosis of human gastric carcinoma SGC-7901 cells,and the mechanism may be related to apoptosis associated gene c-myc.
