Effect of modified HuangqiJianzhong decoction on gastrin gene expression in spleen-qi deficiency rats
- VernacularTitle:加味黄芪建中汤对脾气虚证大鼠胃泌素基因表达的影响
- Author:
Hong SONG
;
Xiaowei ZHENG
;
Ying WANG
;
Suzhen BAO
;
Rongqun LI
;
Zhuxiu JIANG
- Publication Type:Journal Article
- Keywords:
Spleen-qi deficiency syndrome;
Modified HuangqiJianzhong decoction;
Rats;
Gastric antrum;
Serum gastrin;
Gene expression
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of modified HuangqiJianzhong decoction(MHQJZD) with various concentrations at different time points on gastrin(GAS) gene expression level in spleen-qi deficiency rats.Methods: Spleen-qi deficiency syndrome was induced in rats by compound methods which including Radix et Rhizoma Rhei, exhausting and hunger.Spleen-qi deficiency rats were randomly divided into the model control group and the low,medium and high dosage of MHQJZD group.Reverse transcriptase polymerase chain reaction was used to observe the effect of MHQJZD on the GAS mRNA of gastric antrum in rats treated at different time points(7,14,21d).Results: As compared with that in model control group,the GAS gene expression level were both significantly higher in the medium and high dosage groups(P
