Diagnosis and treatment of tuberculosis infection after liver transplantation
- VernacularTitle:肝移植术后结核感染的诊断与治疗
- Author:
Zhidong ZHU
;
Bingyi SHI
;
Guosheng DU
- Publication Type:Journal Article
- Keywords:
liver transplantation;
tuberculosis;
postoperative complications
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the incidence,clinical presentation,diagnosis and treatment strategy of Mycobacterium tuberculosis(TB)infection in liver transplanted recipients.Methods The data of clinical situation,laboratory examination,imaging,diagnosis and management of 3 patients who were infected TB after liver transplantation were retrospectively analyzed.Results The incidence of TB infection after liver transplantation was 1.2 %(3/246).One patient had was pulmonary tuberculosis complicated by pleural tuberculosis,one had pleural tuberculosis complicated with tuberculosis in liver.Both of them had recovered after standard antituberculosis therapy and no relapse up to now.One patient was found to have tuberculous cavity in the lung died of multiple bacterial and fungous infections postoperatively.As clinical presentations of the patients with TB infection were atypical after liver transplantation,it would take about 30d to confirm the final diagnoses after the onset of symptoms.The serologic examination for TB were all negative results in the 3 patients,and the only positive result was of purified protein derivatives(PPD)skin test in one patient.Administration of antituberculous drugs could decrease the plasmic level of immunodepressant,but the level could be kept normal by adjusting the dosage of immunodepressant.In neither of the 3 patients discontinuation of drugs was necessary because of hepatotoxicity of antituberculosis drugs.Anti-TB treatment was effective,safe and feasible.Conclusion The clinical presentation,diagnosis and treatment are specific for patients with TB infection after liver transplantation.Early diagnosis and rational treatment will lead to a better prognosis.
