Curcumin inhibits the adherence of leukocytes to BMECs induced by TNF-? in vitro
- VernacularTitle:姜黄素抑制TNF-?诱导的BMEC与白细胞的粘附
- Author:
Li ZHANG
;
Zhongqin LIANG
;
Zhenlun GU
- Publication Type:Journal Article
- Keywords:
curcumin;
brain microvascular endothelial cells;
leukocytes;
ICAM-1
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of curcumin on the adherence between isolated rat brain microvascular endothelial cells(BMECs)and leukocytes induced by TNF-? in vitro.Methods The adherence ofleukocytes to BMECs and the effects of curcumin were determined by myeloperoxidase.The expression of ICAM-1 was detected by RT-PCR and immunoblotting.Results Curcumin inhibited the TNF-? stimulated adherence of leukocytes to BMECs.Pretreament of curcumin also inhibited TNF-?-induced increases in the mRNA and protein levels of ICAM-1 in BMECs.Conclusions Curcumin could protect the endothelial cells against damage caused by TNF-?.The protective effects of curcumin may be mediated through downregulation of the expression of ICAM-1.
