Effect of the polymerization of HSF1 on the febrile response and the content of vasopressin arginine in brain in LPS-induced fever rabbits
- VernacularTitle:LPS致热家兔诱导HSF1聚合对体温及脑内AVP含量的影响
- Author:
Lianjin JIN
;
Ning BAI
;
Yu CAO
- Publication Type:Journal Article
- Keywords:
lipopolysaccharide(LPS);
fever;
heat shock factor 1(HSF1);
arginine vasopressin(AVP);
quercetin(Que)
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effect of the polymerization of HSF1 on the febrile response in fever rabbits,and further to investigate HSF1 action in thermoregulation and the possible central mechanism.Methods 70 rabbits were divided randomly into 4 groups:the control group(N),the quercetin group(Q),the LPS-feverish group(L),the quercetin+LPS-feverish group(Q+L).Changes in body temperature were continually observed;the expression of HSF1 and HSP70 in hypothalamus was detected by Western blot;the content of AVP in hypothalamus and VSA was measured by radioimmunoassay.Results ① The sequence of the maximum change of temperature(△Tmax)from low to high:group Q
