Effect of Different Doses of Chemotherapeutic Agents on Sensitivity of Glioma U251 Cell Line to Chemotherapy.
- VernacularTitle:化疗药物不同剂量对胶质瘤细胞U251化疗敏感性的影响
- Author:
Xuhong JIN
;
Yuehui MA
;
Ming WANG
- Publication Type:Journal Article
- Keywords:
Chemotherapy;
Dose;
Glioma;
Sensitivity
- From:
Journal of Medical Research
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of chemotherapeutic agents of different doses on sensitivity of glioma U251 cell line to chemotherapy.Methods The rates of cell growth of the U251 cell line under the effect of different chemotherapeutic agents(DOX、VCR、VP-16 and with verapamil)of a series of doses were detected by MTT assay.Results Using DOX or VCR or VP-16 singly,the rates of cell growth were detected at a lever with positively correlates with the concentrations of these chemotherapeutic agents.Moreover the rates of cell growth changed more obviously within some range of concentrations,while the change is limited with the high or low concentrations.The combination of pates of chemotherapeutic agents and verapamil show synergistic effect.Conclusions The relationship between the doses of chemotherapeutic agents and sensitivity of chemotherapy gas a basis for choosing appropriate clinical chemotherapy doses.
