Expression and Significance of Survivin and Fhit Protein in Colorectal Benign and Malignant Disease.
- VernacularTitle:Survivin、fhit在结直肠良恶性病变中的表达及意义
- Author:
Peifei WANG
;
Jianwu CHEN
;
Peizan ZHENG
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
Survivin protein;
Fhit protein;
Immunohistochemistry
- From:
Journal of Medical Research
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of Survivin and Fhit protein in colorectal benign and malignant disease.Methods Test the expression of Survivin and Fhit proteins in 20 cases normal colorectal mucosa,30 cases low grade colorectal intraepithelial lesion,30 cases high grade colorectal intraepithelial lesion and 68 cases colorectal adenocarcinoma by immunohistochemical staining S-P method.Results The unexpression of Survivin in normal colorectal mucosa,postive expression rates of Survivin in low grade colorectal intraepithelial lesion,high grade colorectal intraepithelial lision and colorectal adenocarcinoma were 43.3%,76.7% and 91.2%(P
