Expression of ICAM-1 and LFA-1 in Lymphatic Metastasis of Breast Cancer and its Clinical Significance at Present.
- VernacularTitle:ICAM-1/LFA-1在乳腺癌淋巴转移中表达的研究
- Author:
Jun HE
- Publication Type:Journal Article
- Keywords:
Breast cancer;
ICAM-1;
LFA-1;
Immunohistochemistry
- From:
Journal of Medical Research
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the biological function of ICAM-1and LFA-1 in tumor metastasis,we observed the expression of ICAM-1(Intercellular Adhension Molecule-1)and LFA-1(Lymphocyte function related antigen-1)in cancer tissue and normal tissue.Methods A total of the samples were obtained from hospital,it includes 60 cases of breast cancer and 60 cases of normal mammary tissues.We observed the expression of ICAM-1 and LFA-1 by SP immunohistochemistry.We analyzed the relationship between the expression of ICAM-1,LFA-1and lymphatic vessel metastasis of breast cancer.Results The expression positive rate of ICAM-1and LFA-1 in breast cancer was obviously higher than that in normal mammary tissues(P
