Effects of Curcumin on Behavior and c-fos Expression in Spinal Cord in Chronic Constrictive Injury Rats
- VernacularTitle:姜黄素对神经病理性痛大鼠脊髓背角c-fos表达的影响
- Author:
Xu LI
;
Lingli HE
;
Hong CAO
- Publication Type:Journal Article
- Keywords:
curcumin;
c-fos;
neuralgia;
spinal cord;
rat
- From:
Journal of Zhejiang Chinese Medical University
2007;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[objective] To investigate the effects of curcumin on the behavior of chronic constrictive injury(CCI)rats and the c-fos expression in spinal cord dorsal horn.[Methods]108 male SD rats were randomly divided into 4 groups:Control group(treated with CCI);Sham operation group;Solvent contrast group;Curcumin treated group.Thermal withdrawal latency(TWL)and mechanical withdrawal threshold(MWT)of rats were determined by Hargreave's thermal radiation apparatus and von Frey's method of microfilament,respectively.The time course of expression of c-fos were assessed by immunohistochemical analysis.[Results]Curcumin could significantly attenuate the activation of c-fos induced by CCI and simultaneously ameliorate thermal and mechanical hyperalgesia induced by CCI.[Conclusion]This study shows that curcumin could attenuate the activation of c-fos to ameliorate the CCI-induced neuropathic pain.
