Effects and Mechanisms of PNS on Myocardial Fibrosis in Chronic Viral Myocarditic Mice
- VernacularTitle:三七总皂甙抗病毒性心肌炎慢性期小鼠心肌纤维化作用及其机制的研究
- Author:
Zhiqing CHENG
;
Baihong XU
;
Liping DOU
- Publication Type:Journal Article
- Keywords:
panax notoginsenosides;
myocardial fibrosis;
TGF-?1;
viral myocarditis
- From:
Journal of Zhejiang Chinese Medical University
2007;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To study the mechanisms and effects of panax notoginsenosides(PNS)on myocardial fibrosis in chronic viral myocarditic(VMC)mice.[Methods]The model mice with VMC at chronic status were established by repetitive infection of Coxsckievirus B3m(CVB3m).Heart changes of myocardium and collagen hyperplasia were observed by HE and VG stain.Collagen volume fraction(CVF)and perivascular circuferential area(PVCA)were examined by pathological examination with computed processing.Myocardium TGF-?1 was detected by immunohistochemical method and mRNA expression of TGF-?1 was analyzed by Reverse transcription polymerase chain reaction(RT-PCR)method.[Results]Marked myocardial fibrosis was observed in chronic VMC model group.Compared with blank group,the index of CVF and PVCA was increased significantly(P
