Effect of modified Wendan decoction on expression of p-JNK and p-c-jun in cellular model of AD
- VernacularTitle:温胆汤改良方对Alzheimer病细胞模型JNK、c-jun磷酸化水平的影响
- Author:
Hui HU
;
Ping WANG
;
Yaping HU
;
Heyuan SHI
;
Mingwang KONG
;
Ping LIU
- Publication Type:Journal Article
- Keywords:
Modified Wendan Decoction;
Alzheimer;
NG108-15 cells;
Cell apoptosis;
JNK;
c-jun
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of Modified Wendan Decoction(MWD) on expression of p-JNK and p-c-Jun in cellular model of AD.Methods: NG108-15 cells were exposured to 5?mol/L A?25-35 for 24h to establish the cell model.After treating with contained-MWD serum,cells morphous were observed,survival rate was tested by MTT and cell apoptosis by FCM,the expression of p-JNK and p-c-Jun was measured by method of immuocytochemistry.Results: MWD obviously reduced the expression of p-JNK and p-c-Jun and cell's apoptotic rate.Compared with the model group,the expression of p-JNK and p-c-jun in the SP600125 group and the group treated with contained-MWD serum decreased significantly(P
