Effect of three volatile oils on percutaneous penetration of aconitine through mouse skin in vitro
- VernacularTitle:荜澄茄等3种挥发油对乌头碱经皮渗透的影响
- Author:
Yanjie LI
;
Yicen BAI
;
Yunshu MA
- Publication Type:Journal Article
- Keywords:
Penetration enhancers;
Aconitine;
Volatile oil of Fructus Litseae;
Volatile oil of Rhizoma Zingiberis;
Volatile oil of Rhizoma Acori Tatarinowii
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of volatile oil of Fructus Litseae(FL) ,Rhizoma Zingiberis(RZ) and Rhizoma Acori Talarinowii(RAT) on percutaneous penetration of aconitine through mouse skin in vitro.Methods :By using improved Franz diffusion cells,the effects of these 3 volatile oils on the percutaneous penetration of aconitine were observed and compared with azone,and the cumulative amount of aconitine was determined by HPLC.Results : The penetration coefficient of aconitine with 7%(v/v) volatile oil of FL,RZ and RAT and 3% azone were 10.79,5.82,5.40,3.91,respectively;Compared with the group without penetration enhancers,the differences were significannt;and the enhancement ratios were 3.87,2.09,1.94 and 1.40,respectively,which showed the enhancement ratios of 7% of the 3 volatile oils were higher than that of 3% azone.Conclusion :The 7% volatile oils of FL,RZ and RAT enhance the permeation of aconitine effectively.
