Role of expression of an inhibitory receptor LAIR-1 in graft rejection
- VernacularTitle:抑制性受体LAIR-1表达在移植物排斥反应中的意义
- Author:
Zhouli LI
;
Bingyi SHI
;
Ming CAI
- Publication Type:Journal Article
- Keywords:
enzyme-linked immunosorbent assay;
leukocyte-associated immunoglobulin-like recepter-1;
graft rejection
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on the detection of soluble leukocyte-associated immunoglobulin-like recepter-1 (sLAIR-1) in the serum of the recipient after transplantation, the role of sLAIR-1 in graft rejection was analyzed. Methods Serum sLAIR-1 level was determined by double mAb sandwich enzyme linked immunosorbent assay (ELISA) in 20 healthy volunteers and 162 patients of liver or kidney transplantation, and the results were analyzed and compared. Results In the healthy volunteers and 98 recipients with normal graft function, the sLAIR-1 were detected at the low levels of 4.3?2.3?g/L and 6.3?3.7?g/L, which showed no significant difference (P=0.054). In the 6 cases of acute rejection of liver transplantation, 20 cases of acute rejection of renal transplantation, and 5 cases of graft loss, serum sLAIR-1 was found to be increased remarkably to high levels of 47.2?35.9, 36.3?14.7 and 28.8?19.4?g/L, and they had significant differences compared with that of the healthy volunteers and with the recipients with normal graft function (P
