Effects of recombinant human endostatin on the expression of apoptosisrelated genes in synovial tissue in rats with adjuvant arthritis
- VernacularTitle:重组人内抑素对佐剂性关节炎大鼠滑膜组织凋亡相关基因表达的影响
- Author:
Xueying HUANG
- Publication Type:Journal Article
- Keywords:
recombinant human endostatin;
adjuvant arthritis;
synovial cell;
apoptosis-related gene
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the effects of recombi- nant human endostatin(rh-end)on the expression of p53,fas and bcl-2 genes in synovial tissue in rats with adjuvant arthritis(AA).METHODS:The effects of rh- end on the expression of p53,fas and bcl-2 mRNA in synovial tissue in AA rats were examined quantitatively by SYBR GreenⅠreal-time fluorescent quantitative PCR (FQ-PCR).RESULTS:The expression offas and bcl-2 mRNA in synovial tissue in AA rats treated with rh-end was significantly increased,as compared with model con- trois(P
