Effects of TFAD on the blood-liquid metabolism in experimental hyperlipoproteinemia rats
- VernacularTitle:分蘖葱头总黄酮对实验性高脂血症大鼠血脂代谢的影响
- Author:
Manman SU
;
Xiaofeng YU
;
Shaochun QU
;
Huali XU
;
Dayun SUI
- Publication Type:Journal Article
- Keywords:
TFAD;
hyperlipoproteinemia;
rats
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of totle flavone of allium cepa L.var agrogatum Don(TFAD)on the blood-liquid metabolism in experimental hyperlipoproteinemia rats.Methods The model of experimental hyperlipoproteinemia was established by giving hyperlipid diet to Wistar rats.After the model was established,the rats were treated by TFAD.Then TC、TG、LDL-C、HDL-C of serum,MDA and SOD activties of serum and liver,TXA2 and PGI2 of plasma,blood viscosity were mesured,and pathology of liver was observed.Results After treated by TFAD(25～100 ?g?g-1 po for 21 days),TC、TG、LDL-C、AI、TC/HDL-C and MDA were reduced remarkably,HDL-C and the activity of SOD increased,PGI2 in plasma rose while TXA2 decreased,the blood viscosity of whole blood was depressed significantly,meanwhile the fatty degeneration of hepatic cells was relieved.Conclusions The results suggest that TFAD can adjust the blood-liquid metabolism of experimental hyperlipoproteinemia rats and restrain fatty deposition in liver which may be related to TFAD's function of preventing lipoprotein peroxidization,maitaining physiologic equilibrium of PGI2/TXA2,and ameliorating the abnormity of blood rheology.
