Inhibitory effect of Isorhynchophylline on platelet aggregation and thrombosis
- VernacularTitle:异钩藤碱对血小板聚集与血栓形成的抑制作用
- Author:
Xiaolong XIE
;
Min WU
;
Qin WU
;
Xienan HUANG
;
Qihai GONG
;
Jingshan SHI
- Publication Type:Journal Article
- Keywords:
isorhynchophylline;
platelet aggregation;
thrombosis;
cAMP
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of Isorhynchophylline(Isorhy)on platelet aggregation or thrombosis,and explore the mechanism of it's action.Methods Rat platelet aggregation was determined.cAMP contents were assessed by Born's method and radioimmunoassay respectively.The effect of Isorhy on rat's thrombosis was observed with the thrombogenesis model of artery-vein bypass.Results Isorhy(0.65 mmol?L-1,1.30 mmol?L-1)was shown to markedly inhibit the rat's platelet aggregation induced by ADP or thrombin in a concentration-dependent manner(P
