Positive inotropic action of dimethylamiloride in normal rat isolated hearts and papillary muscle and its primary mechanism
- VernacularTitle:DMA对正常大鼠离体心脏和乳头肌的正性变力作用及其机制
- Author:
Ruizan SHI
;
Fuping GAO
;
Jie LI
;
Mingsheng ZHANG
;
Dongmei WU
- Publication Type:Journal Article
- Keywords:
dimethylamiloride(DMA);
Na~+/Ca~(2+) exchanger(NCX);
positive inotropic action
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the inotropic action of DMA in normal rat isolated hearts and papillary muscle and search for its primary mechanism.Methods With Lansendorff-perfusion and isolated papillary muscle perfusion,cardiac performance and the systolic function of papillary muscle were measured to estimate the inotropic action of DMA;L-calcium channel blocker and sodium calcium exchanger(NCX)inhibitor were used to search for its primary mechanism.Results ①(1~20)?mol?L-1 DMA exerted a positive inotropic action in normal rat isolated hearts,that is in Langendorff-perfused hearts,DMA enhanced cardiac performance,i.e.LVSP-LVDP,+dp/dtmax,-dp/dtmax significantly(P
