Regulation effect of ORL1 and N/OFQ on central nervous system
- VernacularTitle:ORL1及N/OFQ对中枢神经系统的调节作用
- Author:
Quan WEN
;
Zehui GONG
- Publication Type:Journal Article
- Keywords:
ORL1;
N/OFQ;
opioid receptor;
drug targets
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
ORL1(Opioid receptor-like 1)receptor and its endogenous ligand,nociceptin/orphanin FQ,belong to G protein-coupled receptor super family with multiple functions.ORL1 is not only endowed with anti-opioid properties(it suppresses opioid-mediated analgesia),but also involved in cognitive processes,emotion,cardioprotection and neuroendocrine secretion.The research on ORL1 and N/OFQ will certainly be helpful to develop new therapeutic drugs and to find drug targets of clinical application.
