Renal insufficiency and clinical outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention:a multi-centre study
- VernacularTitle:急性冠状动脉综合征接受介入治疗患者肾功能状态多中心注册研究
- Author:
Yong HUO
;
Wa HO
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Angioplasty, transluminal, percutaneous coronary;
Renal insufficiency, chronic;
Stents
- From:
Journal of Peking University(Health Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of renal insufficiency and clinical outcomes in patients with acute coronary syndrome(ACS). Methods: The study was a multi-centre register study including 3 589 ACS patients coming from 39 centers across China who had received percutaneous coronary intervention(PCI) prior to 1st February, 2007. Estimated glomerular filtration rate (eGFR) was calculated for all patients using the 4-variable MDRD equation with the serum creatinine obtained before angiography. The association between renal insufficiency and clinical outcomes and the presence of in-hospital death and bleeding was studied by Fisher’s exact test. Multi-variable analysis on the risk factors of in-hospital bleeding was done by logistic regression test. Results: The mean age of the study population was (61.74?11.37) years (ranging from 23 years to 92 years)and 76.5% (2 746/3 589) of the population was male. Only 90 patients (2.51%) were known to have chronic kidney disease at the time of admission and 144 patients(4.01%) had serum creatintine levels above 133 ?mol/L. However, after the evaluation of renal status by the MDRD equation, 2 250 patients (63.1%)showed a reduction in eGFR of less than 90 mL/min, of whom, 472 (13.1%) even reached the level of moderate renal insufficiency (eGFR
