Study on protective effect and mechanism of rhubarb on intestinal barrier of piglet with sepsis
- VernacularTitle:大黄对脓毒症幼猪肠屏障保护作用及机制研究
- Author:
Yingqian ZHANG
;
Jianhua LIU
;
Diangui LI
;
Bo SUN
- Publication Type:Journal Article
- Keywords:
Sepsis;
Apoptosis;
Cytokine;
Oxidative damage;
Rhubarb;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the protective effect and mechanism of rhubarb on intestinal mucosa epithelial cells apoptosis of piglet with sepsis.Methods: The changes of apoptosis of intestinal mucosa epithelial cells were tested by flow cytometry and TUNLE.Molecular biology methods were used to observe the mRNA expression of zonula occludens(ZO-1),Occludin,TNF-?/IL-10 and the content of MDA,activity of SOD.Results: Compared with model group,the number of apoptosis cells in treatment group decreased apparently(P
