Effect of Glycyrrhiza flavonoids on amounts of immunocytes in S180 tumor-bearing mice
- VernacularTitle:甘草黄酮对荷瘤(S180)小鼠免疫细胞数量的影响
- Author:
Qiang LIU
;
Xingxing CHEN
;
Xuegang SUN
;
Huiqiu HUANG
;
Zhiliang CHEN
- Publication Type:Journal Article
- Keywords:
Glycyrrhiza flavonoids;
Tumor;
Immunocyte
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the anti-tumor effect of Glycyrrhiza flavonoids(GF) and its immunological mechanism.Methods: Mice bearing sarcoma 180(S180) were randomized into 3 GF-treated groups and one control group.The mice in GF-treated groups were perfused with GF.Leukocyte and lymphocyte count were taken by the blood cell analyzer.Flow cytometry was performed to detect the percentages of the T cell subsets.Results: Treatment of GF resulted in the tumor inhibition rates of 52.3%(high dose group).Blood total leukocyte and lymphocyte count in GF treated groups were all higher than that in the control group,and there was the most significant increase of the number of immune cells in the high dose GF group(P
