Study on the association between CYP2E1 enzymes and susceptibility of alcoholic liver disease
- VernacularTitle:酒精性肝病细胞色素P4502E1基因多态性研究
- Author:
Yanmei GUO
;
Qin WANG
;
Aihua FENG
- Publication Type:Journal Article
- Keywords:
Liver disease,alcoholic;
Cytochrome P4502E1;
Gene;
Polymorhism;
Polymerase chain reaction
- From:
Chinese Journal of Practical Internal Medicine
2006;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the CYP2E1 enzymes and alcoholic liver disease.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method was used to determine polymorphism of CYP2E1.A case control study of 183 subjects was carried out including 40 cases of alcoholic liver disease,40 alcohol dependent group,40 nonalcoholic liver disease and 63 controls.Results The frequency of B genotype or C2 allele gene was significantly higher in alcoholic liver disease than in control(P
