STUDY ON BIOAVAILABILITY AND TOXICITY OF SELENIUM FROM METHYLSELENOCYSTEINE
- VernacularTitle:甲基硒半胱氨酸的生物利用率和毒性的研究
- Author:
Huali WANG
;
Jinsong ZHANG
;
Xufang WANG
;
Hanqing YU
- Publication Type:Journal Article
- Keywords:
selenomethionine;
methylselenocysteine;
bioavailability;
toxicity
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:With selenomethionine as reference,we investigated the bioavailability and toxicity of methylselenocysteine. Method:Selenium retention,glutathione peroxidase and thioredoxin reductase activities were tested to compare bioavailability. Acute toxicity and short-term selenium-tolerance were studied to compare toxicity. Results:Selenomethionine and methylselenocysteine were comparable in ability of increasing selenoenzymes. Selenomethionine caused much higher selenium retention,especially at higher levels and lower toxicity indicated by acute toxicity and short-term selenium-tolerance. Conclusion:Compared with selenomethionine,methylselenocysteine has equal efficacy on selenoenzymes with the characterization of less retention,but higher toxicity.
