THE METABONOMIC STUDY ON PORTAL BLOOD PLASMA OF RATS AFTER ORAL ADMINISTRATION OF QUERCETIN
- VernacularTitle:大鼠槲皮素灌胃后门脉血浆代谢组学研究
- Author:
Daizhi AN
;
Qi ZHANG
;
Jingyu WEI
;
Jijun YANG
;
Xianzhong YAN
;
Changjiang GUO
- Publication Type:Journal Article
- Keywords:
quercetin;
metabonomics;
nuclear magnetic resonance
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of quercetin on metabolic profiles of portal blood plasma in rats. Method:Twenty five male Wistar rats were administered orally with 40 mg/kg bw quercetin. Portal blood was collected at 0,0.5h,1 h,2 h and 4 h after dosing respectively and analyzed by 1H NMR. The acquired data were subjected to partial least-squares discriminant analysis. Results:The identified biochemical effects associated with quercetin dosing included increased plasma concentrations of dimethyl sulfoxide,lactate,glucose,alanine,glutamate,succinate,?-hydroxybutyrate,acetone and decreased plasma concentrations of citrate and tyrosine. Conclusion:Quercetin may change the intestinal endogenous metabolism significantly in rats.
