THE COMPARATIVE STUDY ON ANTIHYPERTENSIVE EFFECTS OF THREE ISOLATED VEGETABLE PROTEIN HYDROLYSATES PREPARED WITH ALCALASE
- VernacularTitle:三种植物蛋白质酶解物对自发性高血压大鼠降血压效应的比较
- Author:
Guanhong LI
;
Yonghui SHI
;
Guowei LE
- Publication Type:Journal Article
- Keywords:
protein hydrolysates;
antihypertensive effects;
spontaneously hypertensive rats;
mung bean protein isolates
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the antihypertensive effects of mung bean protein,peanut protein and rice protein alcalase hydrolysates with in vitro angiotensin I-converting enzyme(ACE) inhibitory activity in spontaneously hypertensive rats(SHR) . Method:The impact of digestive proteases on ACE inhibitory activity of hydrolysates of peanut,mung bean and rice protein isolates were evaluated under simulated gastrointestinal digestion and their antihypertensive effects were investigated in SHR after single oral administration. Results:All of three kinds of protein hydrolysates showed antihypertensive activities after single oral administration at a dose of 600 mg/kg bw,most potent in mung bean protein while least in peanut protein. There were no significant changes in the heart rate of SHR after oral administration of protein hydrolysates. Conclusion:Mung bean protein,peanut protein and rice protein hydrolysates all showed antihypertensive activity,but their potent inhibitory activities on ACE did not correlate with their antihypertensive activities found in SHR.
