STUDY ON EFFECTS AND MECHANISM OF SOYBEAN ISOFLAVONES ON UTERI IN PERIMENOPAUSAL RATS
- VernacularTitle:大豆异黄酮对围绝经期大鼠子宫作用及机制研究
- Author:
Ying WANG
;
Ying LIU
;
Qing ZHU
;
Zheng QI
;
Hong DING
- Publication Type:Journal Article
- Keywords:
soybean isoflavones;
perimenopausal uterus;
estrogen receptor subtypes
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of soybean isoflavones(SI) on uteri and uterine Er?,ER? expression in perimenopausal rats. Method:Female SD rats in age of 7-month-old were used as control and 11-month-old SD rats were divided into 5 groups,model group,diethylstilbestrol group and 3 test groups exposed to three doses of SI(ig:30,12,4.6 mg/kg?d) respectively for 35 d. Serum concentrations of estradiol(E2) ,testosterone(T) ,follicle-stimulating hormone(FSH) and luteinizing hormone(LH) were determined. Ultrastructure of uterine luminal surface was observed by scanning electron microscopy and hematoxylin-eosin staining. Expression of ER? and ER? in the uteri were determined by immunohistochemistry. Results:Low dose SI significantly increased serum E2(P
