The Cinical Significance of Plasma Endothelin-1(ET-1) and Nitrous Oxide(NO) in Children Associated with Left to Right Shunt Congenital Heart Defect with Pulmonary Hypertension
- VernacularTitle:左向右分流伴肺动脉高压先天性心脏病患儿内皮素-1和一氧化氮检测临床意义
- Author:
Liangguang QIN
;
Fengyan SHEN
;
Shan HONG
- Publication Type:Journal Article
- Keywords:
Congenital heart defect;
Pulmonary hypertension;
Plasma endothelin-1;
Nitrous oxide
- From:
Journal of Medical Research
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the cinical significance of Plasma Endothelin-1(ET-1) and Nitrous Oxide(NO) in the children associated with left to right shunt congenital heart defect(CHD) with Pulmonary Hypertension(PH).Methods 42 children associated with left to right shunt congenital heart defect with pulmonary hypertension(as patient's group),26 children associated with left to right shunt congenital heart defect without pulmonary hypertension(as heathly group),20 children had the checkup(as control group).Plasma ET-1 and NO2+/NO3+ was cletected in all groups by radioimmunoassay and nitric acid-restored method.Results ET-1 of patient's group was significantly higher than that of control group(P0.05);NO2+/NO3+ of that was significantly lower control group(P
