Changes in function of vascular endothelial cells with glucocorticoid-induced avascular necrosis of femoral head and the preventive and therapeutic effects of traditional Chinese medicines in rabbit
- VernacularTitle:兔激素性股骨头坏死早期血管内皮细胞功能改变及中药对其影响的实验研究
- Author:
Feng JIANG
;
Changlin HUANG
;
Xu CHEN
- Publication Type:Journal Article
- Keywords:
femur head necrosis;
adrenal cortex hormones;
von Willebrand factor;
6-keto-prostaglandin F1?;
plasminogen activator inhibitor 1;
pharmacotherapy,TCD
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of changes in vascular endothelial cells during the development of glucocorticoid-induced avascular necrosis of femoral head(GANFH),and the preventive and therapeutic effects of "Cugusu Keli",a mixture of traditional Chinese medicines,on GANFH in rabbit.Methods Forty-eight New Zealand white rabbits were randomly assigned to four groups,12 in each,as control group,model group,therapy group and prevention group.The contents of plasma von Willebrand's factor(vWF),6-keto-prostaglandin F1?(6-keto-PGF1?)and the activity of plasminogen activator inhibitor 1(PAI-1)were determined at the 2nd,4th,6th,8th and 12th week after treatment.Meanwhile,rabbits were sacrificed at the 4th,8th and 12th week,and both femoral heads of all rabbits were obtained for histopathological examination.Results Compared with control group,the level of vWF and activity of PAI-1 in model group were elevated since the 4th and the 2nd week,while the level of 6-keto-PGF1? increased since the 4th week(P0.05).Compared with the model group,the level of vWF and activity of PAI-1 in therapy group was lowered,while the level of 6-keto-PGF1? increased(P
