Relationship between cognitive disorders in schizophrenia and event-related potential P300
- VernacularTitle:精神分裂症认知功能障碍与事件相关电位P300的相关性研究
- Author:
Li LIU
;
Xiaoxia QIN
;
Yongjin HUANG
;
Hongxi BI
- Publication Type:Journal Article
- Keywords:
schizophrenia;
cognitive disorder;
event-related potentials;
P300
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the cognitive disorders in the first episode of schizophrenia and P300 components.Methods P300 components were measured by using an auditory oddball paradigm with a Denmark KeyPoint Evoked Potentials instrument in 60 cases of schizophrenia and 3 cases of schizophreniform disorder,whose psychopathological status was assessed with the Positive and Negative Syndrome Scale(PANSS).Forty healthy subjects were used as control.Results The principal component analysis of the PANSS items revealed five factors:cognitive disorder,negative symptoms,depressive disorder,hostility/excitement and delusion/hallucination.The patients had lower amplitude of P300 at Fz,Cz,Pz,T3 and T4 than the normal controls(P
