Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features
- VernacularTitle:乙酰肝素酶在膀胱移行细胞癌中的表达及与临床特征的关系
- Author:
Junan YAN
;
Bo SONG
;
Zhiwen CHEN
;
Caiping SONG
- Publication Type:Journal Article
- Keywords:
heparanase;
bladder transitional cell carcinoma;
immunohistochemistry
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of heparanase(HPA)and its correlation with the clinical pathological features and angiogenesis in bladder transitional cell carcinoma.Methods HPA mRNA level was detected with RT-PCR and its protein level was determined by immunohistochemical staining in 68 cases of bladder cancer and 24 cases of adjacent tissues of bladder cancer.Results The positive rate of HPA mRNA was 60.3%(41/68)in bladder cancer,4.2%(1/24)in the adjacent tissues of bladder cancer.The expression of HPA mRNA had statistically significant correlation with pathological stage,clinical staging and lymphonode metastasis(P
