Evaluation of serum pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen and anti-cyclic citrullinated peptide antibody for the diagnosis and treatment of rheumatoid arthritis
- VernacularTitle:Ⅰ型胶原吡啶交联终肽及抗环瓜氨酸肽抗体等联合检测在类风湿关节炎诊断与病情监测中的应用
- Author:
Aiping LE
;
Beihua JU
;
Qingshui HUANG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Pyridinoline cross-linked carboxy-terminal telopeptide of typeⅠcollagen;
Anti-cyclic citrullinated peptide antibody;
Rheumatoid factor;
Diagnosis;
Monitoring
- From:
Chinese Journal of Practical Internal Medicine
2006;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical application of serum pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen(ⅠCTP),anti-cyclic citrullinated peptide(CCP)antibody,rheumatoid factor(RF)and C-reative protein(CRP)detection to the diagnosis and disease monitor of rheumatoid arthritis.Methods Serum ⅠCTP and anti-CCP antibody were measured by ELISA,RF and CRP by immunonephelometry assay in 57 patients with RA and 25 with non-RA as well as 30 normal controls.Results Serum ⅠCTP concentration was positively correlated with that of anti-CCP antibody,RF and CRP(rs=0.474,0.366,0.645,P0.05).Serum ⅠCTP in the patients with active RA was significantly higher than in those with stable RA and normal controls(P0.05).The combined sensitivity of RF and anti-CCP antibody was 87.5%.Conclusion Serum ⅠCTP is a sensitive serum marker to monitor the early damage of arthrosis.Missed diagnosis rate of RA is reduced by detecting anti-CCP antibody and RF together.Combinational monitoring the variance of serum ⅠCTP,anti-CCP antibody,RF and CRP could effectively monitor the disease development in time,which exhibits great sense on impede arthrosis damage.
