Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate
- VernacularTitle:苔藓蒽噻吩-1-羧酸甲酯的合成
- Author:
Rongxin QIN
;
Shenglin LUO
;
Xiangdong ZHOU
- Publication Type:Journal Article
- Keywords:
bryoanthrathiophene;
methyl bryoanthrathiophene-1-carboxylate;
1,8-dihydroxy-9,10-anthraquinone;
regioselective nitration
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the synthesis of methyl bryoanthrathiophene-1-carboxylate with high efficiency. Methods Target compounds were synthesized from 1,8-dihydroxy-9,10-anthraquinone via 5 steps including protecting, nitration, methyl mercaptoacetate substitution, intramolecular Aldol reaction and deprotecting. Results Target molecule was synthesized in the total yield of 45.8%. Conclusion Our synthesis of methyl bryoanthrathiophene-1-carboxylate is characterized by short synthetic route, high selectivity and high efficiency.
