Cardioprotective function of brain natriuretic peptide in patients with heart failure
- VernacularTitle:脑利钠肽对心力衰竭患者心血管保护作用的研究
- Author:
Xiaoqin ZHU
;
Huashan HONG
- Publication Type:Journal Article
- Keywords:
heart failure;
neurohumor;
antihypertrophy;
antifibrotic;
cyclic guanosine monophosphate
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure(HF)is the end stage of many cardiovascular diseases. Both the neurohumor overactivation and ventricular remodeling are the critical pathophy-siological processes of HF. It has been demonstrated that the serum level of brain natriuretic peptide (BNP) is elevated obviously in HF patients. As a circulatory hormone,BNP is mainly produced in cardiac ventricle. Through the natriuretic receptor(NPR)-cyclic guanosine monophosphate(cGMP)pathway, BNP performs the properties of natriuresis,diuresis, vasodilatation,enhancing vagal reflex and inhibiting sympathetic activity, which can improve the hemodynamic of HF without activation of plasma renin. It has been reported that BNP has effects of antihypertrophic and antifibrotic and plays a role in the antiventricular remodeling. In a word, BNP plays an important role of cardioprotection in the development and prognosis of HF though the local autocrine and/orparacrine ways.
