Effect of different compatibilities of effective fraction of Xie-Xin decoction on NF-?B and I?B expression of lung injury rats induced by LPS
- VernacularTitle:泻心汤有效组分不同配伍对内毒素肺损伤大鼠NF-?B及I?B表达的影响
- Author:
Na YANG
;
Xianli MENG
;
Yuxia XIONG
- Publication Type:Journal Article
- Keywords:
lipopolysaccharide;
Xie-Xin decoction;
lung injury;
NF-?B;
I?B
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of effective fraction of Xie-Xin decoction and their compatibilities(EFX)on NF-?B and I?B expression of lung injury rats induced by LPS.Methods Rats were pretreated for 4 days with total flavones(TFL),total free anthraquinones(TFA),total conjugated anthraquinones(TCA),the high(low)dose of compatibility of TFL and TCA(A high,A low),the compatibility of TFL and TCA(B)and dexamethasone respectively 4 days,then injected intravenously with LPS to induce lung injury.6 rats were sacrificed respectively in every group at 1,2,4 h after LPS administration,and the right middle of the lung was harvested at every time point,the expression of NF-?B and I?B was evaluated by Western blot.Results TFA、A high and Dex can inhibit the nuclear translocation of NF-?B at 1,2,4 h(P
