Studies on the rationality of TSD combined with TSA on reducing serum uric acid and anti-inflammatory in mice
- VernacularTitle:萆薢总皂苷合用牛膝总皂苷降血尿酸和抗炎作用的组方合理性研究
- Author:
Guangliang CHEN
;
Haipeng LIU
;
Ru HAN
;
Shuyun XU
- Publication Type:Journal Article
- Keywords:
total saponin of achyranthes bidentata(TSA);
total saponin of dioscorea(TSD);
rationality of combination prescription;
uric acid;
anti-inflammation
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the rationality and the dose of TSD combined with TSA on reducing serum uric acid and anti-inflammatory.Methods Mice hyperuricemic models were made by uric acid intraperitoneal injection or yeast extract paste intragastric administration.Mice ear swelling model was induced by locally painting dimethylbenzene.Optimized combination dosage of TSD and TSA was obtained using the Codrug software.Results In the mice hyperuricemic models,the serum uric acid in TSD group,TSD plus TSA group and positive control groups was significantly reduced compared with the model group(P
