Drug delivery to the brain using PTD transport systems
- VernacularTitle:蛋白质转导结构域的跨血脑屏障药物递送
- Author:
Jianping ZHOU
;
Manji SUN
- Publication Type:Journal Article
- Keywords:
protein transduction domain;
blood brain barrier;
drug delivery
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Blood brain barrier is the main obstacle for drug delivery to the brain.To overcome the limited access of drugs to the brain,three methods have been developed at present:neurosurgical-based strategies,chemistry-based strategies to increase the lipid solubility of the drug,and biology-based strategies of endogenous BBB transporters-mediated drug delivery.PTD transport system to delivery drug across BBB is an emerging technology,which conveniently and efficiently deliver various molecules into spinal cord and brain via blood,intraperitoneally etc.PTD transport system offers a new approach to central nervous system disease with quick,convenient and safe charcteristics.
