Correlation of penicillin allergy and HLA-DRB genetic polymorphism
- VernacularTitle:青霉素过敏反应与HLA-DRB基因多态性
- Author:
Jing YANG
;
Dan ZOU
;
Hailing QIAO
- Publication Type:Journal Article
- Keywords:
allergy;
penicillin;
genetic polymorphism;
HLA-DRB
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the correlationship of allergy to penicillin and HLA-DRB genetic polymorphism.Methods Sequence specific primer-polymerase chain reaction(PCR-SSP)was used to type for human leucocyte antigen-DBR(HLA-DRB)alleles in 77 patients with allergy to penicillin and 87 healthy subjects without any allergic reactions.Results Compared with control subjects,a significantly increased frequency of DR9 was present in 77 patients with allergic reactions(11.04% vs 4.02%,RR=3.24,P
