Relationship between fatty acid synthase and human epidermal growth factor receptor-2 in tumor cells
- VernacularTitle:肿瘤细胞中脂肪酸合成酶和人表皮生长因子受体2的联系
- Author:
Yu ZHANG
;
Zhengfeng YIN
- Publication Type:Journal Article
- Keywords:
neoplasms;
fatty acid synthase;
receptor,epidermal growth factor;
signal transduction;
gene expression
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cells have different physiological and biochemical features as compared to normal cells;abnormal expressi of certain genes is also found in tumor cells.Over-expression of genes provide targets for targeted-administration of drugs,which can avoid damage to normal cells during treatment of tumors.Fatty acid synthase(FAS)and human epidermal growth factor receptor-2(HER2)are both over-expressed in some tumor cells.Herceptin,an HER2-targeted agent,has been used to treat HER2-positive breast cancer patients worldwide and has obtained satisfactory outcome.Cerulomycin,an agent-targeting FAS,is now in FDA clinical trial.Recent researches have shown that FAS and HER2 are simultaneously over-expressed in some tumors,such as breast cancer cells and ovarian cancer cells;and there is a connection between their signal pathways and a synergistic effect between them.This paper reviews the relationship between FAS and HER2 in tumor cells.
