Effects of penetration enhancers on skin permeation behavior of fluoxetine hydrochloride in vitro
- VernacularTitle:透皮促渗剂对盐酸氟西汀经皮渗透性的影响
- Author:
Peng YANG
;
Xueying DING
;
Jing GAO
;
Shen GAO
- Publication Type:Journal Article
- Keywords:
fluoxetine;
penetration enhancer;
administration,cutaneous;
chromatography,high pressure liquid
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of penetration enhancers and their combinations on the transdermal delivery of fluoxetine hydrochloride and to discuss the feasibility of transdermal administration of drugs.Methods:The penetration rate of fluoxetine hydrochloride through rat skin in vitro was measured using Valia-Chien diffusion cells and high pressure liquid chromatography was used for analysis.Results:Penetration enhancers,such as Azone,N-methyl-2-pyrrolidone(NMP),oleic acid,and their combinations all had peneration enhancing effect except for propylene glycol(PG).Azone combined with PG or NMP had the most potent enhancing effect.Conclusion:Satisfactory penetration of fluoxetine hydrochloride through rat skin can be obtained by correct combination of enhancers.
