Distribution of hepatitis B virus genotype and subgenotype and its clinical significane
- VernacularTitle:慢性乙型肝炎病毒基因型和亚型分布及与临床关系的探讨
- Author:
Hongbin KONG
;
Yousheng LI
;
Xingfeng LI
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Genotype;
Subgenotype;
Clinical feature
- From:
Chinese Journal of Practical Internal Medicine
2006;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution of hepatitis B virus genotype and subgenotype in Handan and clarify the genotype-related difference in clinic.Methods PCR-RFLP was used to detect the HBV genotype and subgenotype in 108 HBV-infected patients from Handan Infectious Disease Hospital from January,2006 to April,2006.Analyze the correlation of HBV genotype and clinical characteristicly of patients.Results Among 108 HBV-infected patients,the proportion of genotype B and C is 6.5% and 93.5% respectively.All genotype B patients were subgenotype Ba.In genotype C group,88.1% was subgenotype C2;genotype distribution showed no significant difference between male and female.ALT and AST level were higher in genotype C group than those in genotype B group.Conclusion HBV genotype C is predominant in chronic hepatitis B patients in Handan city.HBV subgenotype C2 is the major subgenotype in Handan city.The positive rate of HBeAg and HBV DNA levels are higher in genotype C than those in genotype B group.Genotype C and genotype B have no difference in the severity of liver disease and HBV-DNA.associated with.Clinical feature of subgenotype C1 and subgenotype C2 is similar.
