The Effects of Low Molecular Weight Heparin on Serum Level of PCⅢ and Type IV Collage and TGF-?_1
- VernacularTitle:低分子肝素对血清ⅣC、PⅢP及TGF-?_1水平的影响
- Author:
Jixian YU
;
Xiaojie BAO
;
Gongying CHEN
;
Jingsong HUAN
;
Xiongying ZHU
;
Xin LUO
- Publication Type:Journal Article
- Keywords:
Low molecular weight heparin;
Liver fibrosis;
TGF-?_1
- From:
Journal of Medical Research
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effects of low molecular weight heparin on liver fibrosis and the serum levels of TGF-?_1 in patients with chronic hepatitis B virus.Methods 45 patients with chronic hepatitis B virus were randomized into control group(the routine strategy)and trial group(the routine strategy + low molecular weight heparin).The period of treatment is 3 weeks.Serum hepatic fibrosis indices before and after heparin treatment were examined by RIA,the levels of serum TGF-?_1 before and after heparin treatment were examined by ELISA.Results Hepatic functions became significantly better in trial groups,serum PⅢP and type IV collage levels and the levels of serum TGF-?_1 in trial group decreased significantly after treatment.Conclusions The mechanism of anti-fibrosis action of LMWH may inhibited production of TGF-?_1 in patients with HBV.
